Lateral and oblique gene transfer
Lateral and oblique gene transfer
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DOI：
10.1016/s0959-437x(00)00243-4
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发表时间：
2001-12-01
影响因子：
4
通讯作者：
Ochman, H
中科院分区：
文献类型：
--
作者：
Ochman, H
来自完整基因组和物种内菌株多个基因座的序列信息正在改变我们研究细菌进化的方式。这种对细菌基因组的大规模评估提供了广泛基因转移和交换的证据。除了极少数情况外，这两个过程似乎并不耦合：某些物种，例如大肠杆菌，经历相对较低水平的基因交换；但致病菌株的出现与通过横向基因转移获得大量毒力因子有关。
Sequence information from complete genomes, and from multiple loci of strains within species, is transforming the way that we investigate the evolution of bacteria. Such large-scale assessments of bacterial genomes have provided evidence of extensive gene transfer and exchange. Except in rare cases, these two processes do not seem to be coupled: certain species, such as Escherichia coli, undergo relatively low levels of gene exchange; but the emergence of pathogenic strains is associated with the acquisition of numerous virulence factors by lateral gene transfer.