Force and length regulation in the microtubule cytoskeleton: lessons from fission yeast
Force and length regulation in the microtubule cytoskeleton: lessons from fission yeast
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DOI：
10.1016/j.ceb.2009.12.011
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发表时间：
2010-02-01
影响因子：
7.5
通讯作者：
Tolic-Norrelykke, Iva M.
中科院分区：
文献类型：
--
作者：
Tolic-Norrelykke, Iva M.
一个活细胞如何处理基本的物理概念，如长度和力？细胞必须测量距离并调节力以动态地组织其内部。这在很大程度上是基于微管（MT）和马达蛋白。两个概念是新兴的，从最近的研究作为关键的细胞组件的定位：首选拆卸较长的MT和首选的高负荷力下的电机分离。这些概念在核定心和核振荡中的作用，从裂变酵母的实验和理论研究中逐渐显露出来。这些普遍的概念可能是至关重要的各种细胞过程，包括核和有丝分裂纺锤体的定位，纺锤体长度的控制，和染色体的中期板上的congression。
How does a living cell deal with basic concepts of physics such as length and force? The cell has to measure distances and regulate forces to dynamically organize its interior. This is to a large extent based on microtubules (MTs) and motor proteins. Two concepts are emerging from recent studies as key to the positioning of cell components: preferred disassembly of longer MTs and preferred detachment of motors under high load force. The role of these concepts in nuclear centering and nuclear oscillations is coming to light from experimental and theoretical studies in fission yeast. These universal concepts are likely crucial for a variety of cell processes, including nuclear and mitotic spindle positioning, control of spindle length, and chromosome congression on the metaphase plate.