Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort
Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort
复制标题
DOI：
10.1093/aje/kwn034
复制
发表时间：
2008-05-15
影响因子：
5
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Oken, Emily;Radesky, Jenny S.;Gillman, Matthew W.
母亲产前食用鱼类对儿童认知发育的污染风险和营养益处的平衡尚不清楚。作者利用1999-2002年在马萨诸塞州登记的341对母子的前瞻性队列研究的数据，研究了母亲中期三个月鱼摄入量和红细胞汞水平与儿童3岁时皮博迪图片词汇测试（PPVT）和视觉运动能力广泛评估（WRAVMA）得分的关系。母亲的平均鱼总摄入量为1.5（标准差，1.4）份/周，40（12%）母亲消费> 2份/周。母亲的平均汞水平为3.8（标准差，3.8）纳克/克。在使用多变量线性回归进行调整后，较高的鱼类摄入量与儿童认知测试表现较好相关，较高的汞水平与测试成绩较差相关。鱼和汞的摄入加强了相关性：每周摄入鱼> 2份与从不摄入鱼的影响估计值为2.2（95%置信区间（CI）：-2.6，7.0），PPVT和6.4（95% CI：2.0，10.8）;对于前十分位的汞，PPVT为-4.5（95% CI：-8.5，-0.4），WRAVMA为-4.6（95% CI：-8.3，-0.9）。鱼类消费量
The balance of contaminant risk and nutritional benefit from maternal prenatal fish consumption for child cognitive development is not known. Using data from a prospective cohort study of 341 mother-child pairs in Massachusetts enrolled in 1999-2002, the authors studied associations of maternal second-trimester fish intake and erythrocyte mercury levels with children's scores on the Peabody Picture Vocabulary Test (PPVT) and Wide Range Assessment of Visual Motor Abilities (WRAVMA) at age 3 years. Mean maternal total fish intake was 1.5 (standard deviation, 1.4) servings/week, and 40 (12%) mothers consumed > 2 servings/week. Mean maternal mercury level was 3.8 (standard deviation, 3.8) ng/g. After adjustment using multivariable linear regression, higher fish intake was associated with better child cognitive test performance, and higher mercury levels with poorer test scores. Associations strengthened with inclusion of both fish and mercury: effect estimates for fish intake of > 2 servings/week versus never were 2.2 (95% confidence interval (CI): -2.6, 7.0) for the PPVT and 6.4 (95% CI: 2.0, 10.8) for the WRAVMA; for mercury in the top decile, they were -4.5 (95% CI: -8.5, -0.4) for the PPVT and -4.6 (95% CI: -8.3, -0.9) for the WRAVMA. Fish consumption of