The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers.
The beta1-adrenergic receptor mediates the pharmacogenetic interaction of the ACE D allele and beta-blockers.
复制标题
β1 肾上腺素能受体介导 ACE D 等位基因和 β 受体阻滞剂的药物遗传学相互作用。
DOI：
10.1111/j.1752-8062.2008.00020.x
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
McNamara,DennisM
中科院分区：
文献类型：
--
作者：
Ishizawar,DavidC;Janosko,KarenM;Teuteberg,JeffreyJ;Cadaret,LindaM;Mathier,MichaelA;McNamara,DennisM
在479例左心室功能不全受试者中研究了血管紧张素转换酶（ACE）插入/缺失多态性与β受体阻滞剂治疗之间相互作用的β受体选择性作用。将受试者分为无β受体阻滞剂、β1选择性和非选择性β受体阻滞剂治疗组。D等位基因对未接受β受体阻滞剂的受试者的无移植生存期产生不利影响（p= 0.004）。选择性β1受体阻滞剂治疗消除了D等位基因的影响（p= 0.51），其方式与非选择性β 1，2受体阻滞剂（p= 0.80）相似。β1受体阻滞剂治疗足以消除ACE D等位基因的不良影响，表明这种药物遗传学相互作用是通过β1受体介导的。
The role of β‐receptor selectivity for the interaction between the angiotensin‐converting enzyme (ACE) insertion/deletion polymorphism and β‐blocker therapy was investigated in 479 subjects with left ventricular dysfunction. Subjects were separated into no β‐blocker, β1 ‐selective, and nonselective β‐blocker treatment groups. The D allele adversely affected transplant‐free survival for subjects not on β‐blockers (p= 0.004). Treatment with selective β1‐blockers eliminated the impact of the D allele (p= 0.51) in a manner similar to nonselective β1,2‐blockers (p= 0.80). Treatment with β1‐blockers was sufficient to eliminate the adverse impact of the ACE D allele, suggesting this pharmacogenetic interaction is mediated through the β1‐receptor.