Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability.
Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability.
复制标题
骨骼肌功能取决于BRCA1以维持基因组稳定性。
DOI：
10.1249/jes.0000000000000265
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发表时间：
2021-10-01
影响因子：
5.7
通讯作者：
Spangenburg EE
中科院分区：
文献类型：
--
作者：
Tarpey MD;Amorese AJ;LaFave ER;Minchew EC;Fisher-Wellman KH;McClung JM;Hvastkovs EG;Spangenburg EE
乳腺癌基因1（BRCA1）是一个大的，多功能的蛋白质，调节多种不同组织中的各种机制。我们的工作确定Brca1在骨骼肌中表达，并定位于线粒体和细胞核。在这里，我们提出BRCA1的表达是至关重要的维持力的生产和线粒体呼吸骨骼肌。乳腺癌基因1（BRCA1）功能的丧失导致骨骼肌特异性力的降低，线粒体能量学的改变和线粒体DNA损伤的积累。
Breast Cancer gene 1 (BRCA1) is a large, multi-functional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle. Loss of Breast Cancer gene 1 (BRCA1) function leads to reductions in skeletal muscle specific force, altered mitochondrial energetics and accumulation of mitochondria DNA damage.