Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.
Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.
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DOI：
10.1523/jneurosci.5952-09.2010
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发表时间：
2010-05-19
期刊：
影响因子：
--
通讯作者：
Kalin NH
中科院分区：
文献类型：
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作者：
Fox AS;Shelton SE;Oakes TR;Converse AK;Davidson RJ;Kalin NH
在儿童中，对潜在威胁的行为抑制（BI）可预测焦虑和情感障碍的发展，灵长类动物损伤研究表明眶额皮质（OFC）参与介导BI。病变研究对于建立脑-行为关系的因果关系至关重要，但应谨慎解释，因为离散病变对复杂神经回路的影响超出了病变位置。评估病变如何影响回路其他部分的补充功能成像方法可以帮助精确了解病变如何影响行为。在猴子中使用这种方法的组合，我们发现OFC病变伴随着改变BI和终纹床核（BNST）区域的代谢，BNST活性的个体差异预测BI。因此，OFC在应对威胁时的一个重要功能是调节BNST，这可能更直接地影响BI的表达。
In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders and primate lesion studies suggest involvement of the orbtiofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion on a complex neural circuit extends beyond the lesion location. Complementary functional imaging methods assessing how lesions influence other parts of the circuit can aid in precisely understanding how lesions affect behavior. Using this combination of approaches in monkeys, we found that OFC lesions concomitantly alter BI and metabolism in the Bed Nucleus of Stria Terminalis (BNST) region and that individual differences in BNST activity predict BI. Thus it appears that an important function of the OFC in response to threat is to modulate the BNST which may more directly influence the expression of BI.