TRANSPLANTATION OF BONE-MARROW WITH CONSTITUTIONALCHROMOSOMAL ANOMALIES - CYTOGENETIC STUDIES AND CLINICAL IMPLICATIONS
TRANSPLANTATION OF BONE-MARROW WITH CONSTITUTIONALCHROMOSOMAL ANOMALIES - CYTOGENETIC STUDIES AND CLINICAL IMPLICATIONS
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DOI：
10.1007/bf00320894
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发表时间：
1986-10-01
期刊：
影响因子：
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通讯作者：
SCHMIDT, CG
中科院分区：
文献类型：
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作者：
BECHER, R;MAHMOUD, HK;SCHMIDT, CG
我们报告两例骨髓移植与体质染色体异常。一名首次完全缓解的急性髓细胞白血病（FAB, M3）女性患者接受了来自其核型为47xxx （triple- x综合征）的姐姐的骨髓移植。一名患有ph阳性CML和体质型Robertsonian t的男性患者（14;15）接受了其姐姐的HLA和MLC位点兼容的骨髓，该姐姐也是Robertsonian携带者（14;15）。我们的研究结果表明，来自染色体易位平衡的供者的骨髓移植是可能的，尽管没有关于长期结果的结论，因为两个受者都死于感染并发症。
We report on two cases of transplantation of bone marrow with constitutional chromosomal anomalies. A female patient with acute myelocytic leukemia (FAB, M3) in first complete remission received a bone marrow graft from her sister with the karyotype 47 XXX (triple-X-syndrome). A male patient with Ph-positive CML and a constitutional Robertsonian t(14;15) received HLA and MLC loci compatible bone marrow from his sister who was also a carrier of the Robertsonian (14;15). Our findings indicate that transplantation of marrow from donors with balanced chromosomal translocation is possible, although no conclusion can be made regarding long term results as both recipients died early from infectious complications.