Response of lamb ductus arteriosus to nitroglycerin and nitroprusside.
Response of lamb ductus arteriosus to nitroglycerin and nitroprusside.
复制标题
羔羊动脉导管对硝酸甘油和硝普钠的反应。
DOI：
10.1016/0022-4804(88)90117-5
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
MentzerJr,RM
中科院分区：
文献类型：
--
作者：
Walsh,RS;Ely,SW;MentzerJr,RM
在某些形式的先天性心脏病中，动脉导管的通畅对于生存至关重要。由于前列腺素的给药与不良副作用有关，因此进行本研究以评价硝酸甘油和硝普钠在氧诱导导管闭合期间对导管血流的影响。对15只近足月胎羊进行急性内固定。连续监测导管血流量和导管前和导管后压力。获得对照数据后，在100%氮气或100%氧气通气期间静脉推注硝酸甘油（250 μ g）、硝普钠（250 μg）或前列腺素E1（5 μg）。所有三种药物均显著增加了氮气通气期间的导管血流量（PO 2 = 15 ± 1 mm Hg）。100%氧通气时，动脉血氧分压升高至107 ± 14 mm Hg，导管血流量由275 ± 44 ml/min降至83 ± 11 ml/min（P< 0.05）。在氧刺激导管关闭期间给予硝酸甘油时，导管血流量增加184%，从79 ± 18 ml/min增加到225 ± 18 ml/min（P< 0.05）：硝普钠使导管血流量从86 ± 20 ml/min增加到195 ± 25 ml/min，增加了126%前列腺素E1使导管血流量从84 ± 18 ml/min增加到178 ± 17 ml/min（P< 0.05）。这些数据表明，硝酸甘油和硝普钠都是有效的动脉导管血管扩张剂，像前列腺素E1，可以显着减弱氧诱导的导管血管收缩。这些结果表明，硝酸甘油和硝普钠可能是有用的临床维持导管通畅。
In certain forms of congenital heart disease, patency of the ductus arteriosus is critical for survival. Since the administration of prostaglandin is associated with adverse side effects, this study was undertaken to evaluate the effects of nitroglycerin and nitroprusside on ductal blood flow during oxygen-induced ductal closure. Fifteen near-term fetal lambs were instrumented acutely. Ductal blood flow and pre- and post-ductal pressures were monitored continuously. After obtaining control data, intravenous bolus injections of nitroglycerin (250 μg), nitroprusside (250 μg), or prostaglandin E1(5 μg) were administered during ventilation with either 100% nitrogen or 100% oxygen. All three agents significantly increased ductal blood flow during nitrogen ventilation (PO2= 15 ± 1 mm Hg). When the lambs were ventilated with 100% oxygen, the arterialPO2increased to 107 ± 14 mm Hg, and this was associated with a marked decreased in ductal blood flow from 275 ± 44 to 83 ± 11 ml/min (P< 0.05). When nitroglycerin was administered during oxygen-stimulated ductal closure, ductal blood flow increased 184%, from 79 ± 18 to 225 ± 18 ml/min (P< 0.05); nitroprusside increased ductal blood flow 126%, from 86 ± 20 to 195 ± 25 ml/min (P< 0.05); prostaglandin E1increased ductal blood flow 110%, from 84 ± 18 to 178 ± 17 ml/min (P< 0.05). These data demonstrate that both nitroglycerin and nitroprusside are potent vasodilators of the ductus arteriosus and, like prostaglandin E1, can markedly attenuate the oxygen-induced ductal vasoconstriction. These results imply that nitroglycerin and nitroprusside may be useful clinically in maintaining ductal patency.