HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians
HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians
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DOI：
10.1034/j.1399-0039.2000.560503.x
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发表时间：
2000-11-01
期刊：
影响因子：
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通讯作者：
Martinez-Laso, J
中科院分区：
文献类型：
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作者：
Arnaiz-Villena, A;Vargas-Alarcón, G;Martinez-Laso, J
研究了墨西哥马扎特坎印第安人（奥尔梅克文化）的HLA等位基因频率分布，并与其他第一美洲原住民和世界各地的人群（3个共12，100条染色体;来自59个不同人群的6，050个个体）进行了比较。主要结论如下：1）奥尔梅克人和玛雅人相关性的间接证据，进一步支持奥尔梅克人可能是玛雅人的先驱的观点; 2）语言和遗传学在微环境研究中并不完全相关; 3）美洲的人口可能比格林伯格和其他人假设的更复杂（三次人口浪潮）。根据系统发育分析，在中美洲和南美洲美洲印第安人中没有注意到来自外部的重要遗传输入;而世界上所有人口（包括非洲人、欧洲人、亚洲人、澳大利亚人、波利尼西亚人、北美Na-Dene印第安人和爱斯基摩人）在遗传上都是相关的。在相邻连接、对应和平面遗传距离分析中，中南美印第安人倾向于保持孤立。
The HLA allele frequency distribution of the Mexican Mazatecan Indians (Olmec culture) has been studied and compared with those of other First American Natives and worldwide populations (3 total of 12,100 chromosomes; 6,050 individuals from 59 different populations). The main conclusions are: 1) An indirect evidence of Olmec and Mayan relatedness is suggested, further supporting the notion that Olmecs may have been the precursors of Mayans; 2) Language and genetics do not completely correlate in microenvironmental studies; and 3) Peopling of the Americas was probably more complex than postulated by Greenberg and others (three peopling waves). Significant genetic input from outside is not noticed in Meso and South American Amerindians according to the phylogenetic analyses; while all world populations (including Africans, Europeans, Asians, Australians, Polynesians, North American Na-Dene Indians and Eskimos) are genetically related. Meso and South American Amerindians tend to remain isolated in the Neighbor-Joining, correspondence and plane genetic distance analyses.