METABOLITES FROM SPONGE PACHYMATISMA-JOHNSTONI - L-6-BROMOHYPAPHORINE, A NEW AMINO-ACID (AND ITS CRYSTAL-STRUCTURE)
METABOLITES FROM SPONGE PACHYMATISMA-JOHNSTONI - L-6-BROMOHYPAPHORINE, A NEW AMINO-ACID (AND ITS CRYSTAL-STRUCTURE)
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DOI：
10.1039/p19770001204
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
KING, TJ
中科院分区：
文献类型：
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作者：
RAVERTY, WD;THOMSON, RH;KING, TJ
从约翰氏假单胞菌中分离得到6-溴下丘脑碱[1-三甲氨基-3-（6-溴吲哚-3-酰基）丙酸]、色氨酸、尿嘧啶、胸腺嘧啶、胆碱-4-烯-3- 1和24-亚甲基胆碱-4-烯-3- 1。x射线分析证实了6-溴-下丘脑素的结构和构型。6-溴-萘醌及其相关化合物在质谱仪中表现出由热反应引起的异常质谱。hypaphorine的热解得到混合物的产物包括吲哚，3-甲基吲哚和吲哚-四氢咔唑羧酸。二乙基（吲哚-3-基甲基）氯化铵热解生成吲哚、3-甲基吲哚、二吲哚-3-基甲烷以及含有3个吲哚单元的相关环链和开链化合物。
6-Bromohypaphorine[1-trimethylammonio-3-(6-bromoindol-3-yl)propionate], tryptophan, uracil, thymine, cholest-4-en-3-one and 24-methylenecholest-4-en-3-one were isolated from P. johnstoni. The structure and configuration of 6-bromohypaphorine were confirmed by X-ray analysis. 6-Bromohypaphorine and related compounds show anomalous mass spectra resulting from thermal reactions in the mass spectrometer. Pyrolysis of hypaphorine gave a mixture of products including indole, 3-methylindole, and an indolyl-tetrahydrocarbazolecarboxylic acid. Pyrolysis of diethyl(indol-3-ylmethyl)ammonium chloride yielded indole, 3-methyl-indole, di-indol-3-ylmethane, and related cyclic and open-chain compounds containing 3 indole units.