Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats
Usefulness of Sweep Imaging With Fourier Transform for Evaluation of Cortical Bone in Diabetic Rats
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DOI：
10.1002/jmri.25955
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发表时间：
2018-08-01
影响因子：
4.4
通讯作者：
Kubo, Toshikazu
中科院分区：
文献类型：
--
作者：
Minami, Masataka;Ikoma, Kazuya;Kubo, Toshikazu
背景糖尿病降低骨强度，可能是由于皮质骨改变。扫描成像与傅里叶变换（SWIFT）已被报道是有用的皮质骨evaluation. Purpose评估皮质骨的变化在糖尿病大鼠使用SWIFT，评估这种技术的有用性通过比较与微型计算机断层扫描（CT）和传统的MRI，并使用组织形态计量学阐明皮质骨变化的潜在机制研究类型动物组动物模型8周龄雄性Wistar/ST大鼠（N=36）随机分为糖尿病组（链脲佐菌素诱导）和对照组。场强/序列7.04T MRI，SWIFT。取出胫骨并使用CT和MRI进行评价。采用CT测量皮质骨密度（BMD）。还进行了质子密度加权成像（PDWI）和SWIFT。计算每次采集的信噪比（SNR）。结果糖尿病组皮质骨密度仅在8周时显著低于对照组（P
BackgroundDiabetes decreases bone strength, possibly because of cortical bone changes. Sweep imaging with Fourier transform (SWIFT) has been reported to be useful for cortical bone evaluation.PurposeTo evaluate cortical bone changes in diabetic rats using SWIFT, assess the usefulness of this technique through comparisons with microcomputed tomography (CT) and conventional MRI, and clarify the mechanism underlying cortical bone changes using histomorphometryStudy TypeAnimal cohort.Animal Model8-week-old male Wistar/ST rats (N=36) were divided into diabetes (induced by streptozotocin injection) and control groups.Field Strength/Sequence7.04T MRI, SWIFT.AssessmentSix animals from each group were sacrificed at 2, 4, and 8 weeks after injection. Tibial bones were extracted and evaluated using CT and MRI. The cortical bone mineral density (BMD) was measured using CT. Proton density-weighted imaging (PDWI) and SWIFT were also performed. The signal-to-noise ratio (SNR) was calculated for each acquisition. The bone formation rate was evaluated using histomorphometry.Statistical TestsFindings at each timepoint were compared using Mann-Whitney U-tests.ResultsCortical BMD was significantly lower in the diabetes group than in the control group only at 8 weeks (P