Prospective study of fibrinolytic markers and venous thromboembolism
Prospective study of fibrinolytic markers and venous thromboembolism
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DOI：
10.1016/s0895-4356(03)00052-0
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发表时间：
2003-06-01
影响因子：
7.2
通讯作者：
Aleksic, N
中科院分区：
文献类型：
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作者：
Folsom, AR;Cushman, M;Aleksic, N
先前的研究对于血浆纤溶因子水平升高是否可以识别有静脉血栓栓塞（VTE）风险的患者存在争议。因此，我们在两项基于人群的前瞻性研究中进行了一项 VTE 巢式病例对照研究。在发生 VTE 的 308 名参与者和 640 名对照参与者中，我们测量了事件前血液样本的 PAI-1 抗原、tPA/PAI-1 复合物、纤溶酶-α(2)-抗纤溶酶 (PAP) 和 PAI-1-675 4G/5G 启动子多态性。在调整年龄或多个 VTE 危险因素后，这些纤溶变量与 VTE 之间不存在总体关联。有微弱的证据表明 PAP 与升高的因子 VIIIc 和升高的 D-二聚体相互作用会增加 VTE 风险。我们的结论是，在大多数情况下，这些纤溶标志物并不能识别出有 VTE 风险的健康受试者。 (C) 2003 Elsevier Inc. 保留所有权利。
Prior research has conflicted on whether increased levels of plasma fibrinolytic factors may identify patients at risk of venous thromboembolism (VTE). We therefore performed a nested case-control study of VTE within two prospective population-based studies. In 308 participants who developed VTE and 640 controls, we measured PAI-1 antigen, tPA/PAI-1 complex, plasmin-alpha(2)-antiplasmin (PAP), and the PAI-1-675 4G/5G promoter polymorphism on pre-event blood samples. There was no overall association between any of these fibrinolytic variables and VTE, after adjustment for age or for multiple VTE risk factors. There was weak evidence for an interaction of PAP with elevated factor VIIIc and elevated D-dimer in augmenting VTE risk. We conclude that, for the most part, these fibrinolytic markers do not identify healthy subjects at risk for VTE. (C) 2003 Elsevier Inc. All rights reserved.