Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
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DOI：
10.1037/0882-7974.14.2.295
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发表时间：
1999-06-01
影响因子：
3.7
通讯作者：
Thal, LJ
中科院分区：
文献类型：
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作者：
Bondi, MW;Salmon, DP;Thal, LJ
携带载脂蛋白E (ApoE) epsilon 4等位基因的非痴呆老年人（n = 43）与没有携带epsilon 4等位基因的参与者（n = 90）在神经心理学上进行了比较。在基线时，各组在年龄、教育程度、性别或全球认知状况上没有差异。ApoE-epsilon 4参与者在延迟回忆方面的平均表现明显较差，但在注意力、语言、结构技能、精神运动速度或执行功能方面没有显著的组间差异。与非epsilon 4参与者相比，ApoE-epsilon 4参与者明显更多地患上了可能或可疑的阿尔茨海默病（AD），这表明组间差异是由epsilon 4组中临床前AD病例的优势造成的，而不是ApoE基因型对认知的直接影响。Cox比例风险分析，调整了年龄、受教育年限和全球认知状况，显示ApoE-epsilon 4等位基因状态和回忆能力是AD转化的显著和独立预测因素。结果支持特定情景记忆改变和ApoE-epsilon 4等位基因在阿尔茨海默病临床前检测中的重要性。
Nondemented older adults genotyped for the Apolipoprotein E (ApoE) epsilon 4 allele (n = 43) were neuropsychologically compared to participants without a copy of the epsilon 4 allele (n = 90). At baseline, the groups did not differ on age, education, gender, or global cognitive status. ApoE-epsilon 4 participants demonstrated significantly poorer mean performances on delayed recall, but no significant group differences emerged on attention, language, constructional skills, psychomotor speed, or executive function. Significantly more ApoE-epsilon 4 participants developed probable or questionable Alzheimer's disease (AD) compared with non-epsilon 4 participants, suggesting that the group differences resulted from a preponderance of preclinical AD cases within the epsilon 4 group and not from a direct influence of ApoE genotype on cognition. Cox proportional hazards analysis, adjusting for age, years of education, and global cognitive status, revealed that ApoE-epsilon 4 allele status and measures of recall performance were significant and independent predictors of conversion to AD. Results support the importance of specific episodic memory changes and possession of the ApoE-epsilon 4 allele in the preclinical detection of AD.