Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus
Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus
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DOI：
10.1016/j.neuroimage.2009.08.021
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Yoshimatsu, Hironobu
中科院分区：
文献类型：
--
作者：
Anan, Futoshi;Masaki, Takayuki;Yoshimatsu, Hironobu
肥胖与认知功能障碍有关，海马体的变化无疑在其中起着关键作用。为验证2型糖尿病非痴呆患者内脏脂肪堆积（VFA）水平升高与海马体积和胰岛素抵抗的相关性，将48例2型糖尿病非痴呆患者分为两组，高VFA组（平均值+/-标准差：年龄= 65 +/- 6岁，n = 30）和正常VFA组（65 +/- 5岁，n = 18）。海马体积已被定量与计算机辅助分析，使用磁共振成像（MRI）的体素为基础的特定区域分析系统开发的阿尔茨海默氏病（VSRAD）的研究，产生一个Z-分数作为评估海马体积的终点。高VFA组的Z评分高于正常VFA组（p < 0.0001）。高VFA组的空腹血糖（p < 0.05）、胰岛素浓度（p < 0.0001）和稳态模型评估（HOMA）指数（p < 0.0001）均高于正常VFA组。多元回归分析显示，VFA水平是由Z评分和HOMA指数独立预测的，我们的研究结果表明，在日本非痴呆2型糖尿病患者的VFA水平升高的特点是增加海马体积和胰岛素抵抗，Z评分和HOMA指数是VFA的独立预测因子。(c)2009 Elsevier Inc. All rights reserved.
Obesity is associated with cognitive dysfunction, for which changes in the hippocampus plausibly play a pivotal role. We tested the hypothesis that ail elevated level of visceral fat accumulation (VFA) correlates with hippocampus volume and insulin resistance in non-dementia patients with type 2 diabetes.Subjects included 48 non-dementia patients with type 2 diabetes, who were divided into two groups, high VFA group (mean +/- standard deviation: age = 65 +/- 6 years, n = 30) and normal VFA group (65 +/- 5 years, n = 18). Hippocampus Volume has been quantitated with computer-assisted analysis using a magnetic resonance imaging (MRI) voxel-based specific regional analysis system developed for the study of Alzheimer's disease (VSRAD), which yields a Z-score as the end point for assessment of hippocampal volume. The Z-score was higher in the high VFA group than in the normal VFA group (p < 0.0001). The fasting plasma glucose (p < 0.05) and insulin concentrations (p < 0.0001) and the homeostasis model assessment (HOMA) index (p < 0.0001) were higher in the high VFA group than in the normal VFA group. Multiple regression analysis showed that VFA levels were independently predicted by Z-score and HOMA index.Our results indicate that the elevated level of VFA in Japanese non-dementia patients with type 2 diabetes is characterized by increased hippocampus Volume and insulin resistance, and that the Z-score and HOMA index are independent predictors of VFA. (c) 2009 Elsevier Inc. All rights reserved.