Interaction of Immune and Connective Tissue Cells
Interaction of Immune and Connective Tissue Cells
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免疫细胞和结缔组织细胞的相互作用
DOI：
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发表时间：
1980
影响因子：
3.6
通讯作者：
J. Korn
中科院分区：
文献类型：
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作者：
J. Korn
炎症和纤维增殖事件是彼此密切相关的生物过程。它们作为宿主对创伤、感染和肿瘤（例如伤口愈合、脓肿形成和肿瘤包封）的正常反应的一部分一起发生。然而，在其他时候，免疫或内膜事件以及结缔组织生物学异常不仅与疾病发病机制和/或表达相关，而且似乎在疾病发病机制和/或表达中发挥核心作用。多种疾病状态下免疫细胞和结缔组织成分之间功能相互关系的概念得到了许多观察结果的支持。首先，许多“结缔组织”疾病（例如类风湿性关节炎、硬皮病、特发性肺纤维化和牛皮癣）的特征在于免疫功能的各种异常。其次，病理检查揭示淋巴细胞和单核细胞（单核细胞）与结缔组织病变之间的密切联系。因此，类风湿性滑膜的增殖性血管翳、硬皮病中涉及的皮肤、间质性纤维化中的肺以及牛皮癣斑块的特征是，至少在病变发生期间的某个时刻，单核细胞的显着浸润。第三，至少一些结缔组织损伤可以通过在实验动物或人身上进行免疫操作来重现：佐剂疾病和胶原蛋白免疫作为类风湿性关节炎的模型，同源疾病和人类移植物抗宿主反应作为硬皮病的模型。最后，细胞培养研究表明，免疫细胞和结缔组织细胞都可以影响彼此的生长和功能。
InfLimmation and fibroproliferative events are biologic processes that are intimately associated with one another.' They occur together as part of the host's normal response to trauma, infection, and neoplasia (eg, wound healing, abscess formation, and tumor encapsulation). At other times, however, immune or intlammalory events and abnormalities of connective tissue biology are not only associated with, but appear to play a central role in, disease pathogenesis and/or expression. The concept of a functional interrelationship between immune cells and connective tissue elements in a variety of disease states is supported by a number of observations. First, many of the "connective tissue" disorders (eg, rheumatoid arthritis, scleroderma, idiopathic pulmonary fibrosis, and psoriasis) are characterized by various aberrations of immune function. Second, pathologic examination reveals a close association between lymphocytes and monocytes {mononuclear cells) and the connective tissue lesion. Thus, the proliferative pannus of rheumatoid synovium, the involved skin in scleroderma, the lungs in interstitial fibrosis, and the psoriaiic plaque are characterized, at least at some point during the genesis of the lesion, by a significant infiltration of mononuclear cells. Third, at least some of the connective tissue lesions may be reproduced by immunologic manipulation in either experimental animals or man: adjuvant disease^ and immunization with collagen'' as models for rheumatoid arthritis, homologous disease^ and the human graft-versus-host reaction-' as models for scleroderma. Finally, cell culture studies indicate that both immune cells and connective tissue cells rnay influence each other's growth and function.