Molecular epidemiology of insulin-dependent diabetes mellitus.
Molecular epidemiology of insulin-dependent diabetes mellitus.
复制标题
胰岛素依赖型糖尿病的分子流行病学。
DOI：
10.1093/oxfordjournals.epirev.a017950
复制
发表时间：
1997
影响因子：
5.5
通讯作者：
Dorman,JS
中科院分区：
文献类型：
--
作者：
Dorman,JS
Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases of childhood, with prevalence rates for US Caucasians approximating 2 per 1,000 (1). Moreover, incidence rates appear to be increasing in countries around the world (2). Significant temporal trends have recently been reported in the United States, Europe, and Asia, reasons for which are not known. Following disease onset, individuals with IDDM may experience acute complications, such as hypoglycemia, ketoacidosis, and cerebral edema; and after a decade with the disease, their risk of developing long-term diabetes complications, including microvascular (ie, retinopathy, nephropathy, and neuropathy) and macrovascular (ie, cardiovascular, cerebrovascular, and peripheral vascular diseases) disorders becomes significant. These conditions contribute to the high rates of morbidity, mortality, and disability that are commonly observed in IDDM populations (3-5). Although it is known that IDDM is an autoimmune disease, the etiology of the disorder remains unclear.Because of the seriousness of IDDM, international studies, such as the World Health Organization Multinational Project for Childhood Diabetes (known as the WHO DiaMond Project (6)) and the EURODIAB ACE Study (a prospective investigation of insulindependent diabetes mellitus) in Europe (7), were recently initiated and have attracted considerable attention to IDDM epidemiology. As a result of these investigations, the extraordinary geographic differences in IDDM incidence have been well documented. There have also been numerous evaluations of the descriptive epidemiology of the disease. In addition, the standardized population-based registries, upon which many of these studies were based, have served
