Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone
Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone
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黑质内单次注射6-羟基多巴胺、1-甲基-4-苯基吡啶鎓离子和鱼藤酮引起大鼠旋转不对称性的差异
DOI：
10.1163/15693910260698258
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Shimohama
中科院分区：
文献类型：
--
作者：
M. Inden;Jun;Y. Kitamura;K. Takata;D. Tsuchiya;Kaneyasu Nishimura;T. Taniguchi;H. Sawada;S. Shimohama
最近，6-羟基多巴胺（6-OHDA）、1-甲基-4-苯基吡啶离子（MPP+）和鱼烯酮被证实是多巴胺能神经毒素。然而，它们在体内大鼠脑中的神经毒性尚不完全清楚。在本研究中，我们比较了6-OHDA、MPP+和鱼藤酮单次黑质内注射的体内神经毒性。注射6-OHDA后，黑质和纹状体多巴胺能神经元损失最大，阿帕吗啡诱导对侧旋转。相比之下，阿吗啡诱导的旋转行为在MPP+的同侧方向上，而鱼藤酮没有观察到。尽管MPP+和鱼藤酮引起黑质多巴胺能神经元的损失，纹状体神经变性有所不同。这些结果表明，这些神经毒素在大鼠体内内注射产生不同程度的多巴胺能神经毒性。
Recently, 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenylpyridinium ion (MPP+) and rotenone have been shown to be dopaminergic neurotoxins. However, their neurotoxicities in rat brains in vivo are not fully understood. In the present study, we compared the in vivo neurotoxicities of 6-OHDA, MPP+ and rotenone using a single intranigral injection. The injection of 6-OHDA caused the greatest loss of dopaminergic neurons in both the substantia nigra and striatum, and apomorphine induced contralateral rotation. In contrast, apomorphine-induced rotational behavior was in the ipsilateral direction with MPP+, and was not observed with rotenone. Although MPP+ and rotenone caused a loss of dopaminergic neurons in the substantia nigra, striatal neurodegeneration varied. These results suggest that intranigral injections of these neurotoxins produce different degrees of dopaminergic neurotoxicity in rats in vivo.