Pain-evoked anterior cingulate activity generating the negative difference potential may reflect response selection processes.
Pain-evoked anterior cingulate activity generating the negative difference potential may reflect response selection processes.
复制标题
疼痛诱发的前扣带回活动产生负电位差可能反映反应选择过程。
DOI：
10.1017/s0048577201393113
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发表时间：
2002
期刊：
影响因子：
3.7
通讯作者：
Dowman,Robert
中科院分区：
文献类型：
--
作者：
Dowman,Robert
在24名参与者中检查了应用于手部的异位冷痛刺激对头皮记录的负差电位（NDP）和腓肠神经电刺激引起的主观疼痛评级的影响。我们以前的工作强烈地表明，NDP产生的部分由前扣带皮层（ACCcd）的认知分裂。根据NDP和NDP的偶极子源定位分析估计ACCcd活性的潜伏期和幅度。正如预期的那样，腓肠神经疼痛等级在冷痛条件下比在对照条件下小。在不同条件下，NDP 125-ms峰下的ACCcd活性没有变化，而210-ms NDP峰下的ACCcd活性在冷痛条件下最大。在这里和其他地方观察到的疼痛诱发的ACCcd活动和疼痛评级之间的分离表明，并非所有的ACCcd中的伤害反应神经元参与疼痛感觉。相反，控制和冷痛条件的认知需求的差异表明，疼痛诱发的210毫秒ACCcd活动反映了反应选择过程，也许反应竞争监测。
The effects of a heterotopic cold pain stimulus applied to the hand on the scalp-recorded negative difference potential (NDP) and subjective pain ratings elicited by electrical stimulation of the sural nerve were examined in 24 participants. Our previous work strongly suggests that the NDP is generated in part by the cognitive division of the anterior cingulate cortex (ACCcd). The latency and magnitude of the ACCcd activity were estimated from the NDP and from the dipole source localization analysis of the NDP. As expected, the sural nerve pain ratings were smaller in the cold pain condition than in the control condition. The ACCcd activity underlying the 125-ms peak of the NDP did not change across conditions, whereas the ACCcd activity underlying the 210-ms NDP peak was largest in the cold pain condition. The dissociation between pain-evoked ACCcd activity and pain ratings observed here and elsewhere suggest that not all of the nociresponsive neurons in the ACCcd are involved in pain sensation. Rather, differences in the cognitive demands of the control and cold pain conditions suggest that the pain-evoked 210-ms ACCcd activity reflects response selection processes, perhaps response competition monitoring.