HYPERTROPHY OF ASTROGLIAL PROCESSES IN DENTATE GYRUS OF SENESCENT RAT
HYPERTROPHY OF ASTROGLIAL PROCESSES IN DENTATE GYRUS OF SENESCENT RAT
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DOI：
10.1002/aja.1001530405
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
DODGE, JT
中科院分区：
文献类型：
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作者：
GEINISMAN, Y;BONDAREFF, W;DODGE, JT
齿状回分子层的颗粒上区的定量EM分析表明，相对于年轻的成年人，衰老大鼠的星形胶质细胞过程的轮廓的数量和体积分数显着增加。这些超微结构的修改，这是不相关的星形胶质细胞的数量或分子层的宽度与年龄相关的显着变化，可能会导致新的星形胶质细胞的过程和/或现有的延长的形成。在任何一种情况下，星形胶质细胞突起轮廓的数量和体积分数的增加是年龄相关的星形胶质细胞肥大的指标。肥大的星形胶质细胞的过程，这似乎是发达国家与先进的年龄作为一个响应部分deafferentation的神经元，可能会补偿减少树突体积分数，从而防止在尺寸的变化齿状回灰质分子层衰老。
Quantitative EM analysis of the supragranular zone of the dentate gyrus molecular layer showed that the number and volume fraction of profiles of astroglial processes are significantly increased in senescent rats relative to young adults. These ultrastructural modifications, which are not associated with significant age-related changes in the number of astrocytes or in the width of the molecular layer, may result from a formation of new astroglial processes and/or elongation of existing ones. In either case, the increase in the number and volume fraction of astroglial process profiles is an indicator of age-related astroglial hypertrophy. Hypertrophy of astroglial processes, which seems to develop with advanced age as a response to partial deafferentation of neurons, may compensate for a decrease in the dendritic volume fraction, thereby preventing changes in the dimensions of the dentate gryus molecular layer in senescence.