Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy
Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy
复制标题
强化体外反搏治疗非动脉炎性前部缺血性视神经病变的评价
DOI：
10.1186/s12886-020-01509-7
复制
发表时间：
2020-06-17
影响因子：
2
通讯作者：
Yang, Hui
中科院分区：
文献类型：
--
作者：
Lin, Lixia;Zhu, Wenhui;Yang, Hui
目的探讨增强型体外反搏（EECP）治疗非动脉炎性前部缺血性视神经病变（NAION）的疗效及其影响因素。方法回顾性分析中山眼科中心就诊的近期发作（< 8周）的NAION患者。患者已决定是否接受EECP治疗，拒绝接受EECP治疗的患者被纳入对照组。通过比较EECP治疗前后患者的视功能和对侧眼受累情况来评价EECP的有效性。结果共纳入61例76眼。29例（37眼）患者接受EECP治疗，32例（39眼）患者被纳入对照组。从NAION发作到开始EECP的平均时间为27.59 ± 16.70天。在EECP组中，平均EECP持续时间为31.57 ± 18.45天。所有患者均对EECP耐受良好。然而，EECP组与对照组之间的视觉功能无显著差异。此外，在不同全身健康状况患者的亚组分析中，没有证据表明EECP有效。在42例单眼NAION患者中，EECP组（27.78%）和对照组（25.00%）的连续发作率相当。结论本研究是首次评价EECP治疗NAION的非随机对照研究。不幸的是，我们在6个月的随访中未能证明EECP在NAION中的有效性。在NAION患者中进一步应用EECP应谨慎。
Background To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Methods Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. Results In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59 +/- 16.70 days. In the EECP group, the mean EECP duration was 31.57 +/- 18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. Conclusion This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.