EFFECT OF AGE ON THE IMMUNOGENICITY OF YEAST RECOMBINANT HEPATITIS-B VACCINES CONTAINING SURFACE-ANTIGEN (S) OR PRES2+S ANTIGENS
EFFECT OF AGE ON THE IMMUNOGENICITY OF YEAST RECOMBINANT HEPATITIS-B VACCINES CONTAINING SURFACE-ANTIGEN (S) OR PRES2+S ANTIGENS
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DOI：
10.1093/infdis/170.3.510
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发表时间：
1994-09-01
影响因子：
6.4
通讯作者：
KRUGMAN, S
中科院分区：
文献类型：
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作者：
CLEMENTS, ML;MISKOVSKY, E;KRUGMAN, S
在282名20-59岁的健康HBV血清阴性成人中进行了一项单盲、多中心、II期试验，研究了酵母重组B肝炎病毒（HBV）疫苗单独含有表面抗原（S）或含有PreS 2（PreS 2 +S）。每个志愿者被随机分配接受含10 μ g S的HBV疫苗或PreS 2 + S的三种剂量之一：2 + 10 μ g，4 + 20 μ g或8 + 40 μ g。HBV表面抗原的抗体水平取决于S的剂量，而不是PreS 2。在每个疫苗组中，20-39岁的志愿者的抗PreS 2和抗S抗体滴度高于40-59岁的志愿者。年龄对乙肝疫苗免疫应答的影响表明，成年人应尽可能早地接种B型肝炎疫苗，老年人可能需要更高剂量或加强免疫以获得持久的免疫力。
A single-blind, multicenter, phase II trial of yeast recombinant hepatitis B virus (HBV) vaccines containing surface antigen (S) alone or with PreS2 (PreS2+S) was conducted in 282 healthy HBV-seronegative adults aged 20-59 years. Each volunteer was randomly assigned to receive HBV vaccine containing 10 mu g of S or one of three doses of PreS2 plus S: 2 + 10 mu g, 4 + 20 mu g, or 8 + 40 mu g. The level of antibody to HBV surface antigen reached depended on the dose of S, not PreS2, received. In each vaccine group, volunteers 20-39 years old had higher titers of anti-PreS2 and antibody to S than those 40-59 years old. The age-related effect on immune response to HBV vaccination suggests that adults should be immunized against hepatitis B at as early an age as possible and that older persons may need a higher dose or booster immunizations to achieve durable immunity.