CD14, new aspects of ligand and signal diversity
CD14, new aspects of ligand and signal diversity
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DOI：
10.1016/s1286-4579(00)00298-7
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发表时间：
2000-03-01
影响因子：
5.8
通讯作者：
Zimmerli, W
中科院分区：
文献类型：
--
作者：
Landmann, R;Müller, B;Zimmerli, W
糖基-磷脂酰肌醇连接的糖蛋白CD 14在骨髓细胞和血清中表达。它结合革兰氏阴性和阳性细菌细胞壁成分和内源性磷脂。Toll样受体、NF-κ B和MAP激酶参与炎症的CD 14信号传导。炎性疾病中CD 14的改变支持这种微生物受体的致病作用。(C)2000年，Elsevier SAS科学与医学版。
The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-KB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor. (C) 2000 Editions scientifiques et medicales Elsevier SAS.