HYPERPROINSULINEMIA OF TYPE-II DIABETES IS NOT PRESENT BEFORE THE DEVELOPMENT OF HYPERGLYCEMIA
HYPERPROINSULINEMIA OF TYPE-II DIABETES IS NOT PRESENT BEFORE THE DEVELOPMENT OF HYPERGLYCEMIA
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DOI：
10.2337/diacare.17.11.1307
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发表时间：
1994-11-01
期刊：
影响因子：
16.2
通讯作者：
GROOP, L
中科院分区：
文献类型：
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作者：
BIRKELAND, KI;TORJESEN, PA;GROOP, L
目的-检查非胰岛素依赖型糖尿病（NIDDM）患者的一级亲属中胰岛素原和胰岛素水平。研究设计和方法-比较四组个体中胰岛素和胰岛素原对口服葡萄糖耐量试验的反应：1）31例初诊单纯饮食治疗的NIDDM患者，2）34例糖耐量减低（IGT）NIDDM患者的一级亲属，3）26例糖耐量正常（NGT）亲属，4）30例无糖尿病家族史的受试者.结果：糖尿病患者空腹和餐后胰岛素原水平均升高，而IGT或NGT亲属中胰岛素原水平均未升高。真胰岛素水平在糖尿病组中最高，其次是IGT受试者，NGT亲属中最低。胰岛素原水平与葡萄糖水平相关，表明高血糖是增加胰岛素原secrety.CONCLUSIONS的主要刺激-一级亲属的NIDDM患者，谁有高风险的发展糖尿病，不表现出空腹或葡萄糖刺激的胰岛素原水平升高，只要他们的空腹血糖水平保持正常。
OBJECTIVE - To examine proinsulin and insulin levels in first-degree relatives of patients with non-insulin-dependent diabetes mellitus (NIDDM).RESEARCH DESIGN AND METHODS - Comparison of insulin and proinsulin responses to an oral glucose tolerance test in four groups of individuals: 1) 31 patients with newly diagnosed NIDDM treated with diet alone, 2) 34 first-degree relatives of NIDDM patients with impaired glucose tolerance (IGT), 3) 26 relatives with normal glucose tolerance (NGT), and 4) 30 subjects without a family history of diabetes.RESULTS- Both fasting and post-glucose levels of proinsulin were elevated in patients with diabetes, but not in the relatives with IGT or NGT. Levels of true insulin were highest in the diabetic group, followed by the subjects with IGT, and were lowest among relatives with NGT. Proinsulin levels correlated with glucose levels, suggesting that hyperglycemia is the main stimulus for increased proinsulin secretion.CONCLUSIONS - First-degree relatives of NIDDM patients, who have a high risk of developing diabetes, do not exhibit elevated levels of fasting or glucose-stimulated proinsulin as long as their fasting glucose levels remain normal.