mRNA修饰研究概况及展望
mRNA修饰研究概况及展望
复制标题
DOI：
--
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
屈良鹄
中科院分区：
文献类型：
--
作者：
孙文举;周克任;杨建华;周 惠;屈良鹄
信使RNA的核苷酸修饰包括2 ′-O-甲基化、假尿苷化、m6 A、m5 C、m7 G、m1A、5 hmC等，研究表明这些修饰在mRNA的稳定性、加工、遗传信息的传递和细胞应激反应中起着重要作用。由于of.technology的限制，我们对过去的mRNA修饰知之甚少。近年来，一系列新技术的出现，为mRNA核苷酸修饰的全面检测和进一步的生物学功能研究提供了极大的便利，并取得了一些重要进展。本文综述了mRNA修饰的研究进展及展望。
Nucleotide modifications of messenger RNA include 2'-O-methylation, pseudouridylation, m6A, m5C,.m7G, m1A, 5hmC, etc. Previous studies have shown that these modifications play an important role in mRNA.stability, processing, transmission of genetic information and cellular stress response. As a result of the limitation of.technology, we know very little for mRNA modification in the past. Recently, a series of new technology provide.great convenience for comprehensive inspection and further biological function research of mRNA nucleotide.modification and have already made some important progress. This review introduced the research progress and.prospects of mRNA modification.