Nanomolar and micromolar effects of 15-deoxy-Δ12,14-prostaglandin J2 on amnion-derived WISH epithelial cells:: Differential roles of peroxisome proliferator-activated receptors γ and δ and nuclear factor κB
Nanomolar and micromolar effects of 15-deoxy-Δ12,14-prostaglandin J2 on amnion-derived WISH epithelial cells:: Differential roles of peroxisome proliferator-activated receptors γ and δ and nuclear factor κB
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DOI：
10.1124/mol.104.009449
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发表时间：
2005-07-01
影响因子：
3.6
通讯作者：
Mitchell, MD
中科院分区：
文献类型：
--
作者：
Berry, EBE;Keelan, JA;Mitchell, MD
15-脱氧δ（12，14）-前列腺素J（2）（15 d-PGJ（2））是一种具有抗炎作用的前列腺素类代谢产物，是过氧化物酶体增殖物激活受体（PPAR）-γ和-δ的激活剂。在子宫内组织中，促炎性细胞因子和胰高血糖素已被确定为在维持妊娠和分娩开始中起关键作用。我们调查并比较了早期（
15-Deoxy Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), an activator of peroxisome proliferator-activated receptor (PPAR)-gamma and -delta, is a prostanoid metabolite with anti-inflammatory actions. In intrauterine tissues, proinflammatory cytokines and prostaglandins have been identified as playing key roles in the maintenance of pregnancy and the onset of labor. We investigated and compared the early (