Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides
Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides
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DOI：
10.1136/oem.60.4.279
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发表时间：
2003-04-01
影响因子：
4.9
通讯作者：
Anger, WK
中科院分区：
文献类型：
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作者：
Farahat, TM;Abdelrasoul, GM;Anger, WK
目的：确定在职业中接触有机磷（OP）农药的工人的神经行为缺陷。方法：本研究是在埃及梅努菲亚省田间棉花作物施用农药期间进行的。将 52 名职业暴露的男性工人与 50 名年龄、社会经济阶层和受教育年限（大于或等于 12 年）相似的未暴露的男性对照进行比较。所有参与者均完成了一份问卷（评估个人、职业和病史）、一般和神经临床检查、神经行为测试组（包括言语抽象、问题解决、注意力、记忆和视觉运动速度测试）、性格评估和血清乙酰胆碱酯酶血清学分析。 结果：在校正年龄和教育程度的混杂因素后，暴露的参与者表现出显着的症状 在六项神经行为测试（相似性、数字符号、轨迹制作 A 和 B 部分、字母取消、数字跨度和本顿视觉保留）中，其表现低于对照组。经过多重比较调整后，使用农药的时间较长与大多数神经行为测试的表现较低有关。尽管暴露者的血清乙酰胆碱酯酶显着低于对照参与者，但它与神经行为表现或神经异常均无显着相关性。结论：职业接触有机磷农药与比以前报道的更广泛的神经行为功能缺陷相关，可能是因为该人群的暴露水平较高。中度慢性 OP 暴露可能不仅会影响之前报道的视觉运动速度，还会影响言语抽象、注意力和记忆力。
Aims: To identify neurobehavioural deficits among workers exposed to organophosphorous (OP) pesticides in their occupation.Methods: This study was conducted during the period when pesticides were applied to cotton crops in the fields in Menoufiya Governorate, Egypt. Fifty two occupationally exposed male workers were compared to 50 unexposed male controls who were similar in age, socioeconomic class, and years of education (greater than or equal to 12 years). All participants completed a questionnaire (assessing personal, occupational, and medical histories), general and neurological clinical examination, neurobehavioural test battery (including tests for verbal abstraction, problem solving, attention, memory, and visuomotor speed), personality assessment, and serological analysis for serum acetylcholinesterase.Results: After correcting for confounders of age and education, the exposed participants exhibited significantly lower performance than controls on six neurobehavioural tests (Similarities, Digit Symbol, Trailmaking part A and B, Letter Cancellation, Digit Span, and Benton Visual Retention). A longer duration of work with pesticides was associated with lower performance on most neurobehavioural tests after adjusting for multiple comparisons. Although serum acetylcholinesterase was significantly lower in the exposed than the control participants, it was not significantly correlated with either neurobehavioural performance or neurological abnormalities.Conclusions: Occupational exposure to OP pesticides was associated with deficits in a wider array of neurobehavioural functions than previously reported, perhaps because of higher exposure in this population. Moderate chronic OP exposure may not only affect visuomotor speed as reported previously, but also verbal abstraction, attention, and memory.