TOPICAL APPLICATION OF 5-FLUOROURACIL IN PREMALIGNANT LESIONS OF CORNEA, CONJUNCTIVA AND EYELID
TOPICAL APPLICATION OF 5-FLUOROURACIL IN PREMALIGNANT LESIONS OF CORNEA, CONJUNCTIVA AND EYELID
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DOI：
10.1007/bf00166683
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发表时间：
1986-12-30
影响因子：
1.4
通讯作者：
VANDELFT, JL
中科院分区：
文献类型：
--
作者：
DEKEIZER, RJW;DEWOLFFROUENDAAL, D;VANDELFT, JL
5例患者局部应用5-氟尿嘧啶。3例有多发性癌前病变的患者，其中2例同时有癌前球部病变，局部应用5%5-FU乳膏和/或1%5-FU滴眼液。在另外2例仅有角膜和结膜癌前病变的患者中，仅使用1%5-FU滴眼液。在动物实验中，未发现1%5-FU对正常角膜和结膜上皮有任何损伤。应用的频率和治疗的时间取决于病变的位置和程度。除因肿瘤上皮分离引起的易治疗的病变外，未见局部5-FU治疗的并发症。4例角膜受累患者的视力均有提高。在这些癌前状态下，诊断和治疗的评估是基于脱落细胞学和活组织检查。
Local application of 5-Fluorouracil was practised on 5 patients. In 3 patients with multiple premalignant oculo-cutaneous lesions, two of whom had also premalignant epibulbar lesions, local 5% 5-Fu cream and/or 1% 5-Fu eyedrops were applied. In 2 other patients who had only premalignant lesions on the cornea and conjunctiva, 1% 5-Fu eyedrops were used only. In animal experiments 1% 5-Fu was not found to cause any damage to normal corneal and conjunctival epithelium. The frequency of the applications and the duration of the treatment were dependent on the location and extent of the lesions. Except for easily treatable lesions, caused by the separation of the tumour epithelium, no complications of local 5-Fu treatment were seen. The visual acuity improved in all 4 patients in whom the cornea was affected. In these premalignant conditions the diagnosis and assessment of the therapy were based on exfoliative cytology and biopsies.