A nearly continuous measure of birth weight for gestational age using a United States national reference.
A nearly continuous measure of birth weight for gestational age using a United States national reference.
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DOI：
10.1186/1471-2431-3-6
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发表时间：
2003-07-08
期刊：
影响因子：
2.4
通讯作者：
Gillman, Matthew W
中科院分区：
文献类型：
--
作者：
Oken, Emily;Kleinman, Ken P;Gillman, Matthew W
背景：充分了解胎儿生长的决定因素和后遗症需要根据胎龄调整出生体重的连续测量。然而，美国公布的参考数据仅提供了每个胎龄出生体重的中位数、最低和最高的第5和第10百分位数的估计值。我们分析的目的是为流行病学分析提供更连续的胎龄出生体重参考指标。方法：我们使用最新的美国全国出生数据集的数据来生成从22周到44周妊娠每一周出生体重的多个参考百分位数。从最后一次月经开始测定胎龄。我们分析了1999年和2000年美国居民母亲所生的6690717名有出生体重和性别记录的单胎婴儿的数据。结果：出生体重随着胎龄的增加而增加，在妊娠晚期斜率增加，超过40周后趋于平稳。男孩的出生体重高于女孩，晚出生的孩子体重高于长子，非西班牙裔白人母亲所生的婴儿体重高于非西班牙裔黑人母亲所生的婴儿。这些结果与先前公布的报告有限百分位数的估计相吻合。结论：我们的方法从广泛的全国数据中获得妊娠22至44周出生体重的综合参考值。其他方法需要假设胎龄和出生体重之间的正常或功能关系，这可能是不合适的。这些数据对研究人员调查胎儿生长改变的预测因素和结果是有用的。
BACKGROUND: Fully understanding the determinants and sequelae of fetal growth requires a continuous measure of birth weight adjusted for gestational age. Published United States reference data, however, provide estimates only of the median and lowest and highest 5th and 10th percentiles for birth weight at each gestational age. The purpose of our analysis was to create more continuous reference measures of birth weight for gestational age for use in epidemiologic analyses.METHODS: We used data from the most recent nationwide United States Natality datasets to generate multiple reference percentiles of birth weight at each completed week of gestation from 22 through 44 weeks. Gestational age was determined from last menstrual period. We analyzed data from 6,690,717 singleton infants with recorded birth weight and sex born to United States resident mothers in 1999 and 2000.RESULTS: Birth weight rose with greater gestational age, with increasing slopes during the third trimester and a leveling off beyond 40 weeks. Boys had higher birth weights than girls, later born children higher weights than firstborns, and infants born to non-Hispanic white mothers higher birth weights than those born to non-Hispanic black mothers. These results correspond well with previously published estimates reporting limited percentiles.CONCLUSIONS: Our method provides comprehensive reference values of birth weight at 22 through 44 completed weeks of gestation, derived from broadly based nationwide data. Other approaches require assumptions of normality or of a functional relationship between gestational age and birth weight, which may not be appropriate. These data should prove useful for researchers investigating the predictors and outcomes of altered fetal growth.