Relationship between objectively measured physical activity and cardiovascular aging in the general population - The EVIDENT trial
Relationship between objectively measured physical activity and cardiovascular aging in the general population - The EVIDENT trial
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DOI：
10.1016/j.atherosclerosis.2014.01.021
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发表时间：
2014-04-01
期刊：
影响因子：
5.3
通讯作者：
Gomez-Marcos, Manuel A.
中科院分区：
文献类型：
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作者：
Garcia-Ortiz, Luis;Recio-Rodriguez, Jose I.;Gomez-Marcos, Manuel A.
背景：年龄增长与动脉硬化的增加有关。我们分析了定期体力活动和心血管老化的关系，评价径向增强指数（rAIx），动态动脉硬化指数（AASI），脉压（PP）和心脏年龄的主题没有atherosclerosis diseases.Methods：一项横断面研究进行，包括1365例受试者的证据试验（平均年龄54.9 +/- 13.7岁，60.3%的妇女）。作为身体活动总量的测量，我们使用参与者佩戴7天的加速计（Actigraph GT 3X）中记录的计数/分钟，以60秒的时间段收集数据，并保留>= 4个有效日的受访者进行分析。使用B-pro器械上的rAIx、AASI以及中央和外周PP的测量值评价动脉硬度。将rAIx调整为75心率（rAIx 75）。心血管风险和心脏年龄通过心脏病风险评分进行评估。计数/min的中位数（IQR）为236.9（176.3-307.8），rAIx 75 90（77-100），睡眠PP 40 mmHg（33-47），中心PP 39 mmHg（32-47），心脏年龄57岁（45-73），ASSI的平均+/- SD为0.44 +/- 0.07。我们发现计数/分钟与rAIx 75（r = -0.086; p < 0.01）、AASI（r = -0.146; p < 0.001）、心脏年龄（r = -0.163; p < 0.001）和外周PP之间呈负相关。在控制了潜在混杂因素后，这些相关性仍然存在，除了rAIx 75。在多元回归分析中，调整后，计数/分钟与AASI、睡眠PP和心脏年龄之间持续存在负相关，但与rAIx 75无关。因此，对于每100个更高的计数/分钟的加速度计测量，AASI和睡眠PP都将降低一个测量单位（β值分别为-0.979和-1.031，p < 0.001）和半年时的估计心龄结论：调整潜在影响变量后，规律的体力活动与晚期心血管衰老相关参数呈负相关。
Background: Aging has been associated with an increase in arterial stiffness. We analyzed the relationship between regular physical activity and cardiovascular aging evaluated by the radial augmentation index (rAIx), ambulatory arterial stiffness index (AASI), pulse pressure (PP) and heart age in subjects without atherosclerotic disease.Methods: A cross-sectional study was performed including 1365 subjects from the EVIDENT trial (mean age 54.9 +/- 13.7 years; 60.3% women). As a measure of total volume of physical activity we used counts/minute recorded in an accelerometer (Actigraph GT3X) that participants wore for seven days, collecting data in 60-sec epochs, and respondents with >= 4 valid days were retained for the analysis. Arterial stiffness was evaluated using measures of rAIx, AASI, and central and peripheral PP on the B-pro device. rAIx was adjusted to 75 heart rate(rAIx75). Cardiovascular risk and heart age was estimated by the Framingham Risk Score.Results: The median (IQR) of counts/min was 236.9 (176.3-307.8), rAIx75 90 (77-100), sleep PP 40 mmHg (33-47), central PP 39 mmHg (32-47) and heart age 57 years (45-73) and the mean +/- SD of the ASSI was 0.44 +/- 0.07. We found an inverse correlation between counts/minute and rAIx75 (r = -0.086; p < 0.01), AASI (r = -0.146; p < 0.001), heart age (r = -0.163; p < 0.001) and peripherals PP. These associations were remained after controlling for potential confounders, except for rAIx75. In the multiple regression analysis, after adjustment, an inverse association persisted between counts/minute and AASI, sleep PP and heart age, but not with rAIx75. Accordingly, for every 100 higher counts/minute of accelerometer measures, both AASI and sleep PP would be lower by one measurement unit (beta = -0.979 and -1.031 respectively, p < 0.001) and the estimated heart age by half year (beta = -0.525, p = 0.023).Conclusions: Regular physical activity was inversely associated with parameters related to advanced cardiovascular aging after adjustment for potentially influencing variables.