Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
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DOI：
10.1021/ac401573r
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发表时间：
2013-07-16
影响因子：
7.4
通讯作者：
Wang, Joseph
中科院分区：
文献类型：
--
作者：
Jia, Wenzhao;Bandodkar, Amay J.;Wang, Joseph
目前的工作描述了在运动过程中使用符合佩戴者皮肤的柔性印刷临时转移纹身电化学生物传感器对人体汗液进行实时无创乳酸传感的第一个例子。这种新的皮肤磨损酶生物传感器对乳酸盐具有高达20毫米的线性化学选择性，并且对表皮磨损产生的连续机械变形具有弹性。该装置已成功应用于人体受试者，用于长时间骑行运动中乳酸汗液动态的实时连续监测。由此产生的时间乳酸曲线反映了运动强度变化时汗液乳酸生成的变化。这种皮肤穿戴的代谢物生物传感器可以对身体表现和整体生理状态提供有用的见解，因此在各种体育、军事和生物医学应用中提供了可观的前景。
The present work describes the first example of real-time noninvasive lactate sensing in human perspiration during exercise events using a flexible printed temporary-transfer tattoo electrochemical biosensor that conforms to the wearer's skin. The new skin-worn enzymatic biosensor exhibits chemical selectivity toward lactate with linearity up to 20 mM and demonstrates resiliency against continuous mechanical deformation expected from epidermal wear. The device was applied successfully to human subjects for real-time continuous monitoring of sweat lactate dynamics during prolonged cycling exercise. The resulting temporal lactate profiles reflect changes in the production of sweat lactate upon varying the exercise intensity. Such skin-worn metabolite biosensors could lead to useful insights into physical performance and overall physiological status, hence offering considerable promise for diverse sport, military, and biomedical applications.