INHIBITORY EFFECT OF HUMAN RECOMBINANT INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA ON GROWTH OF HUMAN VASCULAR ENDOTHELIAL-CELLS
INHIBITORY EFFECT OF HUMAN RECOMBINANT INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA ON GROWTH OF HUMAN VASCULAR ENDOTHELIAL-CELLS
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DOI：
10.1016/0006-291x(87)91060-6
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发表时间：
1987-06-15
影响因子：
3.1
通讯作者：
NAKAMURA, H
中科院分区：
文献类型：
--
作者：
NORIOKA, K;HARA, M;NAKAMURA, H
Endothelial cell growth factor(ECGF) is a potent polypeptide mitogen which stimulates the growth of endothelial cells. The mitogenic effect of ECGF was inhibited by addition of recombinant interleukin-1 (rIL-1) .alpha. or .beta. in a concentration dependent manner. The morphological change was not observed distinctly. In the condition without ECGF, both types of rIL-1 enhanced [3H]-thymidine uptake slightly, but failed to increase cell numbers. These data suggest the possibility that the effect of rIL-1 on Ec is modulated by the presence of ECGF.
