Unsuccessful treatment of four patients with acute graft-vs-host disease after liver transplantation
Unsuccessful treatment of four patients with acute graft-vs-host disease after liver transplantation
复制标题
DOI：
10.3748/wjg.v18.i1.84
复制
发表时间：
2012-01-07
影响因子：
4.3
通讯作者：
Yan, Lu-Nan
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Bo;Yang, Jie;Yan, Lu-Nan
目的：目的：探讨肝移植术后移植物抗宿主病（GVHD）的治疗策略。在这些患者中研究了增加或停用免疫抑制剂联合支持治疗的治疗策略。此外，文献回顾肝移植后发生GVHD的患者进行了performed.RESULTS：虽然初步治疗的短暂反应被检测到，所有4例患者死于GVHD的并发症：一个从脓毒症与多器官功能衰竭，一个从消化道出血，和其他两个从脓毒症与消化道出血。结论：肝移植术后GVHD需要新的有效治疗方法，以改善患者预后。(C)2012年百世登。All rights reserved.
AIM: To investigate appropriate therapeutic strategies for graft-vs -host disease (GVHD) following liver transplantation.METHODS: Four patients who developed GVHD after liver transplantation in West China Hospital were included in this study. Therapeutic strategies with augmentation or withdrawal of immunosuppressants combined with supportive therapy were investigated in these patients. In addition, a literature review of patients who developed GVHD after liver transplantation was performed.RESULTS: Although a transient response to initial treatment was detected, all four patients died of complications from GVHD: one from sepsis with multiple organ failure, one from gastrointestinal bleeding, and the other two from sepsis with gastrointestinal bleeding. Few consensuses for the treatment of GVHD after liver transplantation have been reached.CONCLUSION: New and effective treatments are required for GVHD after liver transplantation to improve the prognosis of patients with this diagnosis. (C) 2012 Baishideng. All rights reserved.