TREATMENT OF PREVIOUSLY INTRACTABLE DEPRESSIONS WITH TRANYLCYPROMINE AND LITHIUM
TREATMENT OF PREVIOUSLY INTRACTABLE DEPRESSIONS WITH TRANYLCYPROMINE AND LITHIUM
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DOI：
10.1097/00005053-197209000-00009
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发表时间：
1972-01-01
影响因子：
1.9
通讯作者：
SWARTZBURG, M
中科院分区：
文献类型：
--
作者：
HIMMELHOCH, JM;DETRE, T;SWARTZBURG, M
本文报告21例具有所谓双相特征的抑郁症患者，用反苯环丙胺治疗。其中20人已经在使用碳酸锂，20人过去对这些三环类抗抑郁药没有反应。18例患者出现嗜睡，3例抑郁时睡眠模式无改变。16/21例对反苯环丙胺的反应为良好至极好。5例失败中有4例表现出“易怒-偏执”症状，过去被诊断为“情感障碍”。单胺氧化酶抑制剂和锂的作用机制的问题提出。此外，还讨论了除“单极”和“双相”抑郁症亚型的可能存在。
Twenty-one depressed patients with so-called “bipolar characteristics” and treated with tranylcypromine are reported. Twenty of these were already on lithium carbonate and 20 had failed to respond to these tricyclic antidepressants in the past. Eighteen patients were hypersomnic and 3 experienced no change in sleep pattern when depressed. Sixteen out of 21 had a good to excellent response to tranylcypromine. Four out of 5 failures demonstrated an “irritable-paranoid” tableau and were diagnosed “schizoaffective” in the past. Questions about the mechanism of action of monoamine oxidase inhibitors and of lithium are raised. The possible existence of subtypes of depression in addition to “unipolar” and “bipolar” is also discussed.