Actions of delta-9-tetrahydrocannabinol in cannabis: relation to use, abuse, dependence.
Actions of delta-9-tetrahydrocannabinol in cannabis: relation to use, abuse, dependence.
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DOI：
10.1080/09540260902782752
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Haney M
中科院分区：
文献类型：
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作者：
Cooper ZD;Haney M
大麻使用障碍最近已被确定为一个相关的临床问题：一部分大麻吸烟者寻求治疗其大麻使用，但很少有人成功地保持长期禁欲。吸食大麻的主要精神活性成分δ-9-四氢大麻酚（THC）的奖励和积极强化作用是由大麻素CB 1受体介导的。CB 1受体也被证明介导大麻素依赖和停药后戒断的表达，这是一种跨物种验证的现象。本文将审查的结果表明，CB 1受体在外源性大麻素的行为影响，重点是大麻素的依赖性和强化，因素，有助于维持慢性大麻吸烟，尽管有负面影响。阿片调节这些影响也进行了讨论。
Cannabis use disorders have been recently identified as a relevant clinical issue: a subset of cannabis smokers seeks treatment for their cannabis use, yet few succeed in maintaining long-term abstinence. The rewarding and positive reinforcing effects of the primary psychoactive component of smoked cannabis, delta-9-tetrahydrocannabinol (THC) are mediated by the cannabinoid CB1 receptor. The CB1 receptor has also been shown to mediate cannabinoid dependence and expression of withdrawal upon cessation of drug administration, a phenomenon verified across species. This paper will review findings implicating the CB1 receptor in the behavioural effects of exogenous cannabinoids with a focus on cannabinoid dependence and reinforcement, factors that contribute to the maintenance of chronic cannabis smoking despite negative consequences. Opioidergic modulation of these effects is also discussed.