Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis.
Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis.
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DOI：
10.1097/mib.0000000000001155
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发表时间：
2017-07
影响因子：
4.9
通讯作者：
Chassaing B
中科院分区：
文献类型：
--
作者：
Miles JP;Zou J;Kumar MV;Pellizzon M;Ulman E;Ricci M;Gewirtz AT;Chassaing B
缺乏膳食纤维被认为会增加患各种慢性炎症性疾病的风险，而补充膳食纤维可能会提供一系列促进健康的益处。与这一主题相一致，我们最近报告说，在小鼠中，由纯化成分制成且缺乏可发酵纤维的组成定义饮食（CDD）促进低度炎症和代谢综合征，这两者都可以通过补充此类饮食与可发酵纤维菊粉来改善。在此，我们检查了相对于基于谷物的小鼠饮食（食物），CDD消耗是否会影响葡聚糖硫酸钠（DSS）诱导的肠道炎症的发展，此外，DSS诱导的结肠炎是否也可以通过补充菊粉的饮食来减弱。与其促进低度炎症类似，高脂肪和低脂肪含量的CDD与纤维素相比增加了DSS诱导的结肠炎的严重程度。然而，与低度炎症的情况相反，在低脂肪和高脂肪饮食中，添加菊粉而不是不溶性纤维素进一步加剧了结肠炎的严重程度及其相关的临床表现（体重减轻和出血）。虽然菊粉和其他可发酵纤维可以改善低度炎症和相关的代谢疾病，但它也有可能加剧急性结肠炎诱导剂引起的疾病严重程度。
Lack of dietary fiber has been suggested to increase the risk of developing various chronic inflammatory diseases, while supplementation of diets with fiber might offer an array of health promoting benefits. Consistent with this theme, we recently reported that, in mice, compositionally defined diets (CDD) that are made with purified ingredients and lack fermentable fiber promote low-grade inflammation and metabolic syndrome, both of which could be ameliorated by supplementation of such diets with the fermentable fiber inulin. Herein, we examined if, relative to a grain-based mouse diet (chow), CDD consumption would impact development of intestinal inflammation induced by dextran sodium sulfate (DSS) and, moreover, whether DSS-induced colitis might also be attenuated by diets supplemented with inulin. Analogous to their promotion of low-grade inflammation, CDD of high- and low-fat content with cellulose increased the severity of DSS-induced colitis relative to chow. However, in contrast to the case of low-grade inflammation, addition of inulin, but not the insoluble fiber cellulose, further exacerbated the severity of colitis and its associated clinical manifestations (weight loss and bleeding) in both low and high fat diets. While inulin, and perhaps other fermentable fibers, can ameliorate low-grade inflammation and associated metabolic disease, it also has the potential to exacerbate disease severity in response to inducers of acute colitis.