Fragmentation of Golgi membranes by norrisolide and designed analogues.
Fragmentation of Golgi membranes by norrisolide and designed analogues.
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Norrisolide 和设计的类似物对高尔基体膜的碎片化。
DOI：
10.1016/j.bmcl.2004.08.003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Theodorakis,EmmanuelA
中科院分区：
文献类型：
--
作者：
Brady,ThomasP;Wallace,ErinK;Kim,SunHee;Guizzunti,Gianni;Malhotra,Vivek;Theodorakis,EmmanuelA
The effect of norrisolide (4) and designed analogues on the Golgi membranes is presented. We found that 4 is the first compound known to induce an irreversible vesiculation of these membranes. To investigate the chemical origins of this new effect we synthesized and evaluated a series of norrisolide analogues in which the chemical functionalities present in the parent structure were altered. Such structure/function studies suggest that the perhydroindane core of 4 is critical for binding to the target protein, while the C21 acetate unit is essential for the irreversible vesiculation of the Golgi membranes.
