Herpes Simplex Virus Cell Entry Mechanisms: An Update.
Herpes Simplex Virus Cell Entry Mechanisms: An Update.
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单纯疱疹病毒进入细胞机制：更新。
DOI：
10.3389/fcimb.2020.617578
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发表时间：
2020
影响因子：
5.7
通讯作者：
Shukla D
中科院分区：
文献类型：
--
作者：
Madavaraju K;Koganti R;Volety I;Yadavalli T;Shukla D
单纯疱疹病毒（HSV）可感染多种宿主，并在人类中引起从轻度到危及生命的感染。HSV的表面糖蛋白在进化上是保守的，并且显示出在宿主细胞表面结合不止一种受体的非凡能力。附着之后，病毒将其脂质包膜与宿主细胞膜融合，并将其核衣壳连同皮层蛋白一起释放到细胞质中。在皮层蛋白和宿主细胞因子的帮助下，核衣壳随后停靠在核孔上。然后病毒双链DNA被释放到宿主细胞的细胞核中。释放的病毒DNA要么快速复制（在非神经元细胞中更常见），要么在细胞核内潜伏（在感觉神经元中）。病毒包膜与宿主细胞膜的融合是关键步骤。阻断这一步骤可以防止HSV进入宿主细胞以及随后最终导致病毒子代产生和细胞死亡或潜伏的相互作用。在这篇综述中，我们讨论了病毒进入机制，包括不依赖pH以及依赖pH的内吞进入、HSV的细胞间传播以及将病毒糖蛋白用作抗病毒靶点。
Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target.
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通讯作者：
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