Cytocompatibility of HeLa cells to nano-sized ceramics particles
Cytocompatibility of HeLa cells to nano-sized ceramics particles
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HeLa 细胞与纳米陶瓷颗粒的细胞相容性
DOI：
10.1166/jnn.2016.12309
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Y. Yoshida and H. Sano
中科院分区：
文献类型：
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作者：
E. Seitoku;S. Abe;T. Kusaka;M. Nakamura;S. Inoue;Y. Yoshida and H. Sano
在这项研究中，我们研究了人宫颈癌（HeLa）细胞暴露于纳米颗粒的行为和细胞相容性反应。暴露于氧化钛和氧化铟纳米颗粒的培养细胞仍然具有很高的存活率。在氧化铜（CuO）存在下；然而，细胞变得严重发炎。为了了解CuO导致细胞死亡的机制，我们评估了细胞死亡和凋亡细胞术。CuO比二氧化钛纳米颗粒更能诱导细胞凋亡。共聚焦荧光显微镜显示纳米级颗粒穿透细胞。
In this study, we investigated the behaviors and cytocompatibility response of human cervical carcinoma (HeLa) cells expose to nano-sized particles. Cultivated cells exposed to titanium oxide and indium oxide nanoparticles remained highly viable. In the presence of copper oxide (CuO); however, the cells became seriously inflamed. To understand the mechanism by which CuO causes cell death, we evaluated cell death and apoptosis cytometry. CuO induced cells apoptosis more strongly than exposure to titania nanoparticles. Confocal fluorescence microscopy revealed that the nano-sized particles penetrate the cells.