Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
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用于活性氧清除和减轻炎症相关疾病的超小型铜基纳米颗粒
DOI：
10.1038/s41467-020-16544-7
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发表时间：
2020-06-03
影响因子：
16.6
通讯作者：
Deng, Jun
中科院分区：
文献类型：
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作者：
Liu, Tengfei;Xiao, Bowen;Deng, Jun
氧化应激与许多急性和慢性炎症性疾病相关，但目前临床上可用的治疗有限。开发具有良好活性氧清除能力和生物相容性的仿酶纳米材料（nanozymes）是治疗活性氧相关炎症的一种很有前途的方法。在这里，我们报告了一个简单而有效的一步开发超小的Cu5.4O纳米粒子（Cu5.4O USNPs）与多个酶模拟和广谱活性氧清除能力的ROS相关疾病的治疗。同时具有过氧化氢酶，超氧化物歧化酶和谷胱甘肽过氧化物酶模拟酶特性的Cu5.4O USNP在极低剂量下对ROS介导的损伤表现出细胞保护作用，并显着改善急性肾损伤，急性肝损伤和伤口愈合的治疗结果。同时，Cu5.4O USNP的超小尺寸使得纳米材料能够快速肾清除，保证了生物相容性。Cu5.4O USNPs的保护作用和良好的生物相容性将促进ROS相关疾病的临床治疗，并使下一代纳米酶的开发成为可能。
Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment is currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) with good reactive oxygen species (ROS) scavenging ability and biocompatibility is a promising way for the treatment of ROS-related inflammation. Herein we report a simple and efficient one-step development of ultrasmall Cu5.4O nanoparticles (Cu5.4O USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for the treatment of ROS-related diseases. Cu5.4O USNPs simultaneously possessing catalase-, superoxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effects against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in acute kidney injury, acute liver injury and wound healing. Meanwhile, the ultrasmall size of Cu5.4O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the biocompatibility. The protective effect and good biocompatibility of Cu5.4O USNPs will facilitate clinical treatment of ROS-related diseases and enable the development of next-generation nanozymes.