Negative regulation of Wnt signalling by HMG2L1, a novel NLK‐binding protein
Negative regulation of Wnt signalling by HMG2L1, a novel NLK‐binding protein
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DOI：
10.1046/j.1365-2443.2003.00666.x
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发表时间：
2003-08
期刊：
影响因子：
2.1
通讯作者：
Misato Yamada;B. Ohkawara;N. Ichimura;Junko Hyodo‐Miura;S. Urushiyama;K. Shirakabe;H. Shibuya
中科院分区：
文献类型：
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作者：
Misato Yamada;B. Ohkawara;N. Ichimura;Junko Hyodo‐Miura;S. Urushiyama;K. Shirakabe;H. Shibuya
背景：Wnt信号在许多发育过程和肿瘤发生中起着关键作用。Wnt/β-catenin信号传导诱导胞质β-catenin的稳定，其与TCF/LEF-1转录因子相互作用，从而诱导Wnt靶基因的表达。最近的证据表明，一个特定的MAP激酶途径，涉及MAP激酶TAK 1和MAP激酶NLK抵消Wnt信号。
Background: Wnt signalling plays a critical role in many developmental processes and tumorigenesis. Wnt/β‐catenin signalling induces the stabilization of cytosolic β‐catenin, which interacts with TCF/LEF‐1 transcription factors, thereby inducing expression of Wnt‐target genes. Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK1 and the MAP kinase NLK counteract Wnt signalling.