A study of analysis parameters that influence the sensitivity of event-related fMRI analyses
A study of analysis parameters that influence the sensitivity of event-related fMRI analyses
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DOI：
10.1006/nimg.2000.0549
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发表时间：
2000-04-01
期刊：
影响因子：
5.7
通讯作者：
Friston, KJ
中科院分区：
文献类型：
--
作者：
Hopfinger, JB;Büchel, C;Friston, KJ
为了评估各种分析参数对事件相关fMRI分析敏感性的影响，对单个fMRI数据集进行了36次分析，沿四个轴改变参数：(1)重采样体素大小；(2)空间平滑；(3)时间平滑；和。(4)用于对事件相关响应建模的基函数集。灵敏度（即在给定激活存在的情况下检测到激活的概率）是根据Z分数和校正P值的度量来评估的。期望欧拉特性的负对数。16个大脑区域分布在皮层和皮层下区域被纳入meta分析。发现重采样体素大小、空间平滑、时间平滑和所选择的基函数集对灵敏度有主要影响。通常产生最敏感分析的分析参数是2毫米(3)重采样体素大小，10毫米空间平滑，4秒时间平滑，以及由血流动力学响应函数及其时间导数组成的基集。(C) 2000年学术出版社。
To assess the effect of various analysis parameters on the sensitivity of event-related fMRI analyses, 36 analyses were performed on a single fMRI data-set, varying parameters along four axes: (1) resampled voxel size; (2) spatial smoothing; (3) temporal smoothing; and. (4) the set of basis functions used to model event-related responses. Sensitivity (i.e., the probability of detecting an activation given it exists) was assessed in terms of Z scores and by a metric for corrected P values,. the negative log of the expected Euler characteristic. Sixteen brain regions distributed across cortical and subcortical areas were included in the meta-analysis. Main effects on sensitivity were found for resampled voxel size, spatial smoothing, temporal smoothing, and the set of basis functions chosen. The analysis parameters that generally produced the most sensitive analyses were a 2-mm(3) resampled voxel size, 10-mm spatial smoothing, 4-s temporal smoothing, and a basis set comprising a hemodynamic response function and its temporal derivative. (C) 2000 Academic Press.