DETECTION OF A CELL-SURFACE ANTIGEN CORRELATED WITH ORGAN-SPECIFIC METASTASIS
DETECTION OF A CELL-SURFACE ANTIGEN CORRELATED WITH ORGAN-SPECIFIC METASTASIS
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DOI：
10.1038/286267a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
LONGENECKER, BM
中科院分区：
文献类型：
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作者：
SHEARMAN, PJ;GALLATIN, WM;LONGENECKER, BM
尽管具有转移潜能的肿瘤细胞可能会随机循环，但许多细胞表现出对特定器官的偏好。最近报道了一种由马立克S病(MD)病毒转化的非生成性淋巴瘤细胞系的肝脏特异性转移变体。MD是一种自然发生的、由疱疹病毒诱导的鸡T细胞淋巴瘤，其病理和病因与人的Burkitt S淋巴瘤有相似之处。这使MD成为一种有用的研究模型。其中一个相似之处是两者的转移模式都导致卵巢和肝脏病变的高发生率。细胞表面抗原的存在可被单抗检测，与器官特异性转移相关。
Despite the fact that tumor cells with the potential for metastasis may circulate randomly, many demonstrate a preference for specific organs. The derivation of a liver-specific metastatic variant of a Marek''s disease (MD) virus-transformed, non-producer lymphoma cell line was recently reported. MD is a naturally occurring, herpes virus-induced, T-cell lymphoma of chickens which bears pathological and etiological similarities to Burkitt''s lymphoma in man. This makes MD a useful model for study. One similarity is the pattern of metastasis in which both lymphomas induce a high incidence of ovarian and liver lesions. The existence of a cell-surface antigen, detectable by a monoclonal antibody, correlated with organ-specific metastasis.