Phage P1 temperature-sensitive mutants with defects in the lytic pathway.
Phage P1 temperature-sensitive mutants with defects in the lytic pathway.
复制标题
噬菌体 P1 温度敏感突变体在裂解途径中存在缺陷。
DOI：
10.1016/0042-6822(80)90155-5
复制
发表时间：
1980
期刊：
影响因子：
3.7
通讯作者：
Scott,JR
中科院分区：
文献类型：
--
作者：
Razza,JB;Watkins,CA;Scott,JR
We have partially characterized the first 10 mutants of bacteriophage P1 that are temperature sensitive in functions required for lytic growth. The 10 mutants fall into six different complementation groups, one of which includes a previously described amber mutant. The approximate position of these five groups was established by deletion mapping. Based on temperature shift experiments with the is mutants, each of the six affected genes is required for lytic growth only later than 30 min after infection. Two of these genes, 11 and 12, probably code for structural proteins of the Pi virion since temperature-sensitive mutants in these genes show greater thermolability than wild type P1 phage. One of thetsmutations is suppressed by the presence of an amber suppressor in the host.
