HIV Incidence Among Individuals Accessing Pre-Exposure Prophylaxis in Jackson, Mississippi.
HIV Incidence Among Individuals Accessing Pre-Exposure Prophylaxis in Jackson, Mississippi.
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密西西比州杰克逊接受暴露前预防的个人的艾滋病毒发病率。
DOI：
10.1089/apc.2023.0026
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发表时间：
2023
影响因子：
4.9
通讯作者：
Khosropour,ChristineM
中科院分区：
文献类型：
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作者：
Riley,Taylor;Bender,Melverta;Wang,Xueyuan;Mena,Leandro;Gipson,June;Barnes,Alicia;Johnson,KendraL;Backus,KandisV;Gomillia,CourtneyE;Ward,LoriM;Khosropour,ChristineM
虽然暴露前预防（PrEP）是一种有效的生物医学干预措施，但当天PrEP计划的有效性尚未得到广泛研究。我们利用了2018年9月至2021年9月期间密西西比州四家最大的PrEP提供商中的三家的数据，这些数据与密西西比州卫生部的增强艾滋病毒/艾滋病报告系统有关。艾滋病毒诊断定义为在初次PrEP就诊后至少2周检测出新艾滋病毒阳性。我们计算了HIV的累积发病率和每100人年的发病率（PY）。人次计算为从首次PrEP就诊到(1)HIV诊断或(2)2021年12月31日（HIV监测数据结束日期）的时间。我们没有对停止PrEP的个体进行审查，以获得PrEP的有效性而不是有效性的估计。在研究期间开始PrEP的427名客户中，2.3%[95%置信区间（CI）： 0.9-3.8]随后检测出HIV阳性。HIV感染率为1.18 / 100 PY (95% CI: 0.64-2.19)，首次PrEP就诊后到HIV诊断的中位时间为321天（95% CI: 62-686）。与顺性男性和女性相比，跨性别和非二元性别人群的艾滋病毒感染率最高[10.35 / 100 PY (95% CI: 2.59-41.40)]，与白人和其他种族人群相比，黑人人群的艾滋病毒感染率最高[1.45 / 100 PY (95% CI: 0.76-2.80)]。这些发现表明，需要更多的临床和社区干预措施，以支持艾滋病毒感染高危人群坚持和重新开始PrEP。
Although pre-exposure prophylaxis (PrEP) is an efficacious biomedical intervention, the effectiveness of same-day PrEP programs has not been widely studied. We utilized data from three of the four largest PrEP providers in Mississippi from September 2018 to September 2021 linked to the Mississippi State Department of Health's Enhanced HIV/AIDS reporting system. HIV diagnosis was defined as testing newly positive for HIV at least 2 weeks after the initial PrEP visit. We calculated the cumulative incidence and incidence rate of HIV per 100 person-years (PY). Person-time was calculated as time from the initial PrEP visit to (1) HIV diagnosis or (2) December 31, 2021 (HIV surveillance data end date). We did not censor individuals if they discontinued PrEP to obtain an estimate of PrEP effectiveness rather than efficacy. Among the 427 clients initiating PrEP during the study period, 2.3% [95% confidence interval (CI): 0.9–3.8] subsequently tested positive for HIV. The HIV incidence rate was 1.18 per 100 PY (95% CI: 0.64–2.19) and median time to HIV diagnosis after the initial PrEP visit was 321 days (95% CI: 62–686). HIV incidence rates were highest among transgender and nonbinary individuals [10.35 per 100 PY (95% CI: 2.59–41.40)] compared with cisgender men and women, and among people racialized as Black [1.45 per 100 PY (95% CI: 0.76–2.80)] compared with White and other racialized groups. These findings indicate a need for more clinical and community interventions that support PrEP persistence and restarts among those at high risk of HIV acquisition.
社区健康中心人群坚持每日口服 TDF/FTC 进行 PrEP：可持续健康中心实施 PrEP 试点 (SHIPP) 研究
影响因子：
4.4
作者：
D. Smith;M. Rawlings;N. Glick;L. Mena;M. Coleman;M. Houlberg;S. McCallister;J. Wiener
通讯作者：
J. Wiener
跨性别和性别多样化年轻人中与艾滋病毒传播相关的性行为：种族主义和跨性别恐惧症的交叉作用
影响因子：
4.4
作者：
Elle Lett;E. Asabor;Nguyen K. Tran;Nadia L. Dowshen;Jaya Aysola;Allegra R. Gordon;Madina Agénor
通讯作者：
Madina Agénor