A Highly Effective, Nontoxic T1 MR Contrast Agent Based on Ultrasmall PEGylated Iron Oxide Nanoparticles
A Highly Effective, Nontoxic T1 MR Contrast Agent Based on Ultrasmall PEGylated Iron Oxide Nanoparticles
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DOI：
10.1021/nl902715v
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发表时间：
2009-12-01
期刊：
影响因子：
10.8
通讯作者：
Weller, Horst
中科院分区：
文献类型：
--
作者：
Tromsdorf, Ulrich I.;Bruns, Oliver T.;Weller, Horst
在这项研究中，我们系统地开发了一种基于非常小的聚乙二醇化氧化铁纳米颗粒的潜在MR T-1造影剂。我们调整了提供合适的弛豫性质的晶体核心的大小。此外，致密和优化的PEG涂层在生理条件下提供了高稳定性，以及低细胞毒性和低非特异性吞噬巨噬细胞作为网状内皮系统的一部分，在生物学相关浓度下。所开发的造影剂在1.41 T下具有最低的r（2）/r（1）比（2.4），这是迄今为止报道的PEG化氧化铁纳米颗粒，以及r（1）弛豫率（7.3 mM（-1）s（-1）），其比作为基于钆作为临床标准的典型T-1造影剂的Magnevist高两倍。
In this study we systematically developed a potential MR T-1 contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r(2)/r(1) ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r(1) relaxivity (7.3 mM(-1) s(-1)) that is two times higher compared to that of Magnevist as a typical T-1 contrast agent based on gadolinium as a clinical standard.