Survival in hereditary breast and colon cancer.
Survival in hereditary breast and colon cancer.
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遗传性乳腺癌和结肠癌的存活率。
DOI：
10.1001/jama.1981.03320110013015
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
P. Lynch
中科院分区：
文献类型：
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作者：
H. Lynch;W. Albano;J. Recabaren;P. Fain;P. Lynch
致编辑对辐射和药物的有害宿主反应在遗传性疾病中是常见的，例如，因淋巴瘤治疗的共济失调毛细血管扩张症（AT）患者的辐射损伤和死亡，遗传性视网膜母细胞瘤中的辐射诱导肿瘤，痣样基底细胞癌综合征，以及在药物的情况下，与治疗性腺发育不全的己烯雌酚相关的子宫内膜癌。非治疗药物在作为致癌物时，由于主要遗传因素的影响，其代谢会发生差异。1，2间接地，关于遗传性癌症患者的非凡存活率的轶事报告表明宿主对全身性癌症扩散具有抵抗力的可能性。3 Langlands et al 4已经证明了一系列具有阳性家族史的乳腺癌患者的平均生存率增加。在我们的癌症易感家族登记中，将106例乳腺癌患者（20个无关家族）和117例结肠癌患者（18个无关家族）的5年生存率与2010年的5年生存率进行了比较。
To the Editor.— Deleterious host responses to radiation and drugs are commonplace in genetic diseases, eg, radiation damage and death in patients with ataxia telangiectasia (AT) treated for lymphoma, radiation-induced tumors in inherited retinoblastoma, and the nevoid basal cell carcinoma syndrome, and in the case of drugs, endometrial carcinoma associated with stilbesterol in the treatment of gonadal dysgenesis. Nontherapeutic agents, when acting as carcinogens, are differentially metabolized as a result of primary genetic factors. 1,2 Contrarily, anecdotal reports of extraordinary survival in patients with hereditary cancer suggest the possibility of host resistance to systemic cancer spread. 3 Langlands et al 4 have demonstrated increased mean survival in a series of breast cancer patients with a positive family history. In our registry of cancer-prone families, the five-year survival rate for 106 breast cancer patients (20 unrelated families) and 117 colon cancer patients (18 unrelated families) was compared with that of the