A prospective study of inflammatory Cytokines and diabetes Mellitus in a multiethnic cohort of postmenopausal women
A prospective study of inflammatory Cytokines and diabetes Mellitus in a multiethnic cohort of postmenopausal women
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DOI：
10.1001/archinte.167.15.1676
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发表时间：
2007-08-13
影响因子：
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通讯作者：
Manson, JoAnn E.
中科院分区：
文献类型：
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作者：
Liu, Simin;Tinker, Lesley;Manson, JoAnn E.
背景资料：炎症细胞因子，包括肿瘤坏死因子α、IL-6（白细胞介素6）和高敏C反应蛋白（hsCRP），与胰岛素抵抗和2型糖尿病有关。然而，全面评估其在2型糖尿病发展中作用的前瞻性研究很少，特别是在少数民族人群中。在82069名年龄在50 - 79岁之间的绝经后妇女中，没有心血管疾病或糖尿病，他们参加了妇女健康倡议观察性研究，我们前瞻性地检查了肿瘤坏死因子α受体2，IL-6和hsCRP与糖尿病风险的关系。在一个中位数为5.9年的随访期内，1584名患有临床糖尿病的妇女按年龄、种族、临床中心、抽血时间和随访时间与2198名无糖尿病的研究参与者相匹配。最高和最低四分位数的估计相对危险度为1.47（95%置信区间[CI]，1.10-1.97），肿瘤坏死因子α受体2，3.08（95% CI，2.25-4.23），hsCRP为3.46（95% CI，2.50-4.80）（趋势P，
Background: Inflammatory cytokines, including tumor necrosis factor alpha, IL-6 ( interleukin 6), and high-sensitivity C-reactive protein (hsCRP), have been related to both insulin resistance and type 2 diabetes mellitus. However, prospective studies that comprehensively assess their roles in the development of type 2 diabetes are few, especially in minority populations.Methods: Among 82069 postmenopausal women aged 50 to 79 years without cardiovascular disease or diabetes mellitus who participated in the Women's Health Initiative Observational Study, we prospectively examined the relationships of plasma levels of tumor necrosis factor alpha receptor 2, IL-6, and hsCRP to diabetes risk. During a median follow-up period of 5.9 years, 1584 women who had clinical diabetes were matched by age, ethnicity, clinical center, time of blood draw, and duration of follow-up to 2198 study participants who were free of the disease.Results: After adjustment for matching factors and known diabetes risk factors, all 3 markers were significantly associated with increased diabetes risk; the estimated relative risks comparing the highest with the lowest quartiles were 1.47 (95% confidence interval [CI], 1.10-1.97) for tumor necrosis factor alpha receptor 2, 3.08 ( 95% CI, 2.25-4.23) for IL-6, and 3.46 (95% CI, 2.50-4.80) for hsCRP (P for trend,