Investigation of CMV disease in immunocompromised patients
Investigation of CMV disease in immunocompromised patients
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DOI：
10.1136/jcp.54.2.84
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发表时间：
2001-02-01
影响因子：
3.4
通讯作者：
Emery, VC
中科院分区：
文献类型：
--
作者：
Emery, VC
巨细胞病毒（CMV）是免疫功能低下个体发病和死亡的公认原因。这篇综述将集中在理解宿主和寄生虫之间复杂的相互作用和宿主免疫系统扰动的病理后果的最新进展。CMV是一种缓慢复制病毒的经典观点受到最近体内研究结果的挑战，这些发现表明，CMV在人类宿主中动态地进行主动复制，其复制时间约为一天。此外，巨细胞病毒载量在病毒发病机制中起着重要作用，因此，在迄今研究的所有免疫功能低下组中，巨细胞病毒复制增加是疾病的重要危险因素。这些研究的重点是了解病毒复制增强的病毒学和免疫学决定因素及其病理后果。
Cytomegalovirus (CMV) is a recognised cause of morbidity and mortality in immunocompromised individuals. This review will concentrate on recent advances in the understanding of the complex interplay between the host and parasite and the pathological consequences of perturbation of the host immune system. The classic view of CMV as a slowly replicating virus is challenged by recent in vivo findings suggesting that active replication occurs dynamically in the human host, with a doubling time of approximately one day. In addition, CMV load plays a major role in viral pathogenesis, such that increased CMV replication is a significant risk factor for disease in all immunocompromised groups studied to date. These studies focus attention on understanding the virological and immunological determinants of enhanced viral replication and its pathological consequences.