Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm
Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm
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DOI：
10.7554/elife.52059
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发表时间：
2020-06-24
期刊：
影响因子：
7.7
通讯作者：
Uludag, Kamil
中科院分区：
文献类型：
--
作者：
Jacobs, Heidi Il;Priovoulos, Nikos;Uludag, Kamil
大量动物和人类的证据表明去甲肾上腺素（NE）蓝斑（LC）系统在调节记忆以唤起经验中起作用，但LC是否会沿着记忆阶段重塑其作用仍不清楚。镇静排除了在动物记忆处理过程中检查LC动力学。在这里，我们通过专用超高场LC成像方法的独特组合，一个完善的情感记忆任务，在线生理和唾液α-淀粉酶测量年轻人在唤醒相关的记忆处理过程中的LC的贡献。在编码过程中，杏仁核参与后，与芳香族化合物相关的LC激活。在巩固和回忆，激活过渡到海马参与，反映学习和模型更新。NE-LC激活是动态的，起着唤醒控制的作用，是不够的，但需要与杏仁核的相互作用，以形成情绪体验的适应性记忆。这些发现对理解LC失调对精神和神经认知障碍中观察到的情感记忆形成中断的贡献具有意义。
A body of animal and human evidence points to the norepinephrine (NE) locus coeruleus (LC) system in modulating memory for arousing experiences, but whether the LC would recast its role along memory stages remains unknown. Sedation precluded examination of LC dynamics during memory processing in animals. Here, we addressed the contribution of the LC during arousal-associated memory processing through a unique combination of dedicated ultrahigh-field LC-imaging methods, a well-established emotional memory task, online physiological and saliva alpha-amylase measurements in young adults. Arousal-related LC activation followed amygdala engagement during encoding. During consolidation and recollection, activation transitioned to hippocampal involvement, reflecting learning and model updating. NE-LC activation is dynamic, plays an arousal-controlling role, and is not sufficient but requires interactions with the amygdala to form adaptive memories of emotional experiences. These findings have implications for understanding contributions of LC dysregulation to disruptions in emotional memory formation, observed in psychiatric and neurocognitive disorders.