Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population.
Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population.
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DOI：
10.1038/s41598-018-20443-9
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发表时间：
2018-02-02
影响因子：
4.6
通讯作者：
Carpenter DO
中科院分区：
文献类型：
--
作者：
Byrne SC;Miller P;Seguinot-Medina S;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
多溴联苯醚(PBDEs)是一种普遍存在的环境污染物。北极土著人民通过海洋哺乳动物的传统饮食接触到多溴二苯醚。多溴二苯醚会破坏甲状腺的动态平衡。这项研究的目的是评估圣劳伦斯岛尤皮克岛偏远人口血清多溴二苯醚与甲状腺功能的关系。采集了阿拉斯加州圣劳伦斯岛85人的血清样本，测定了PBDEs、游离和总甲状腺素(T4)、游离和总三碘甲腺原氨酸(T3)和促甲状腺激素(TSH)的浓度。多溴联苯醚与甲状腺激素之间的关系用多元线性回归与广义估计方程进行拟合。几种五溴二苯醚同系物(BDE-28/33、47和100)的血清浓度与TSH和游离T3浓度呈正相关，而BDE-153的血清浓度与总T3浓度呈负相关。当BDE-47、BDE-153和BDE-209是同一模型中的协变量时，BDE-47和153仍然与甲状腺激素显著相关。血清中多溴二苯醚浓度与游离T4或总T4均无显著关系。个别多溴二苯醚与阿拉斯加原住民偏远人群血清中的甲状腺激素有关，其作用方向因同种物质而异。
Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants. Arctic indigenous peoples are exposed to PBDEs through a traditional diet high in marine mammals. PBDEs disrupt thyroid homeostasis. The aim of this study was to assess the relationship between serum PBDEs and thyroid function in a remote population of St. Lawrence Island Yupik. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska and measured for concentrations of PBDEs, free and total thyroxine (T4), free and total triiodothyronine (T3), and thyroid stimulating hormone (TSH). The relationships between PBDEs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations. Both BDE-47 and 153 remained significantly associated with thyroid hormones when BDE-47, BDE-153, and BDE-209 were covariates in the same model. There were no significant relationships between serum concentrations of PBDEs and either free or total T4. Individual PBDEs are associated with thyroid hormones in serum from a remote population of Alaska Natives, and directions of effect differ by congener.